DRUG:  IBESARTAN

  1. What is the medicine Irbesartan?
  2. Side effects of Irbesartan
  3. What is the uses of Irbesartan?
  4. What are the contraindications to the use of Arbesartan?
  5. What are the side effects of irbesartan?
  6. What are the precautions for using Arbesartan?
  7. What are the drug interactions of Larbesartan?
  8. What are the doses of Arbesartan and methods of use?
  9. What are the dosage forms of Larbesartan?
  10. What are the storage conditions of Arbesartan?

What is the medicine Irbesartan?

Irbesartan, a drug called an angiotensin II blocking of angiotensin II receptor blocker, produces a direct receptors. 

IRBESARTAN uses,side effects ,drug interactions
IRBESARTAN uses,side effects ,drug interactions

 

The antihypertensive effect is caused by blocking angiotensin receptors. Angiotensin causes blood vessels to narrow , and the release of adosterone causes absorption of water and sodium and increases blood pressure. Therefore, blocking angiotensin 2 receptors counteracts all of the above and causes low blood pressure. 

                                                                           

This restricting effect results in a higher efficacy of the effect of angiotensin II on the heart and blood vessels, and fewer side effects than ACE inhibitors.

Drug classification: angiotensin II receptor blockers

Category: Hypertension

Pharmacological family:

How to dispense the medicine The medicine is dispensed with a prescription. (RX)

Side effects of Irbesartan

  • Hyperkalemia 19%
  • rotary 10%
  • upper respiratory tract infection (URTI)
  • Orthostatic hypotension 5%
  • fatigue 4%
  • diarrhea 3%
  • glut 2%
  • urticaria; angioedema
  • Impaired renal function, including cases of renal failure, have been reported
  • Increased creatine phosphokinase

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What is the uses of Irbesartan? 

                                                                        

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  • It is used alone or with other antihypertensive drugs to treat high blood pressure.
  • It is used to treat kidney disease in people with type 2 diabetes and high blood pressure.

What are the contraindications to the use of Arbesartan?

It is forbidden to use the medicine without consulting a specialist in the following cases:

  • Hypersensitivity to any of the components.
  • a history of liver disease;
  • Severe loss of body fluids and salts ( dehydration ).

What are the precautions for using Arbesartan? 

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Use with caution under the supervision of a physician in the following cases:

  • Low blood pressure or slow heartbeat: Severe hypotension may occur; Bradycardia and angina pectoris can accompany increased blood pressure. Postural hypotension may also occur.
  • Blood volume depletion and moderate hypotension.
  • Myocardial infarction and suspected right ventricular infarction.
  • Increased potassium level: Blood pressure, kidney function and the amount of potassium in the blood should be monitored regularly (this medicine may cause increased potassium levels in some patients).
  • Decreased renal function: This medicine may cause decreased renal function or an increase in serum creatinine, especially in patients with reduced renal blood flow (renal artery stenosis, heart failure).
  • With the following conditions: Aortic (mitral) stenosis: Patients with pronounced narrowing of the aorta or mitral valve.
  • Heart failure, hypovolemia, renal artery stenosis , or kidney failure.
  • Pregnancy : It should be avoided, as there are no adequate studies on its use.
  • Lactation: It is not known if it is excreted in breast milk, it is preferable to avoid it.

What are the drug interactions of Larbesartan?

It is preferable to tell the doctor or pharmacist about all medicines, herbs, vitamins, and nutritional supplements before starting treatment, as the patient may need to adjust the dose or perform certain tests. 

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It is recommended not to concomitantly with the following drugs: 

                                                                       

  • Other medicines that lower blood pressure. This may enhance the effect of the medicine on blood pressure, such as beta-blockers, alpha-blockers, diuretics such as furosemide, and ACE inhibitors, such as enalapril and captopril.
  • Phosphodiesterase-5 inhibitors, such as sildenafil (Viagra), tadalafil, or vardenafil.
  • Non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac or ibuprofen.
  • Other medicines that can increase potassium levels in the blood or potassium supplements.
  • Potassium-sparing diuretics such as: spironolactone, triamterene, amiloride, trimethoprim, sodium phosphate, rituximab, and pentoxifylline .
  • Monoamine oxidase inhibitors such as isocarboxazid.
  • eplerenone;
  • lithium salts.
  • amifostine diazoxide.

What are the doses of Arbesartan and methods of use?

  • For the treatment of high blood pressure: The doctor prescribes one tablet per day at a concentration of 150 mg as an initial dose, which may later be increased to 300 mg.
  • Kidney impairment in patients with type 2 diabetes: The dose ranges between 75-300 mg daily.

What are the dosage forms of Larbesartan?

Concentration tablets: 75 mg, 150 mg, 300 mg.

What are the storage conditions of Arbesartan?

Store at temperature between 15-30 °C, away from moisture and out of reach of children